Hormone Therapy

Hormone therapy is effective in treating menorrhagia less than 50% of the time, with varying degrees of menstrual bleeding reduction. The treatment itself is associated with potential side effects that affect a woman’s quality of life, including headaches, weight gain, and nausea. Unlike a one-time NovaSure Endometrial Ablation, hormone therapy requires ongoing therapy. Women may stop taking oral contraceptives or other hormone therapies for many reasons. Many women worry about long-term health effects from the medications or they have experienced side effects. Compliance is a complex issue that needs physician follow-up. Almost one third of women stop taking hormones due to side effects or lack of efficacy.

Hormones don't reliably help with heavy menstrual bleeding

53% of women failed to achieve normal bleeding1

Results from a 3-month randomized, controlled clinical trial of a 35 mcg ethinyl estradiol formulation

Hormone Therapy can take months to achieve bleeding control2,3

OCs - 3 months required to see
reductions in bleeding.
2

With Medical Management Treatment Failure is High,
Resulting in Additional Intervention4

Bar chart illustrating the failure rate of hormones as a treatment option for menorrhagia

Data from a 5-year study of menorrhagia with women randomized to receive medical therapy or transcervical resection (N=144). Medical therapies included OCs, progestins, an antifibrinolytic, GnRH agonist or HRT.

Drug therapy may not be an option for some patients, since oral contraceptives are contraindicated in women with a history of cardiovascular disease, blood clots, diabetes, and breast cancer. There are also serious questions regarding the potential health risks associated with long-term use of hormone therapy. Moreover, physicians have reported recently that fewer patients want to go on hormone therapy to control their menorrhagia.


Reference: 1. Davis A, Godwin A, Lippman J, et al. Triphasic norgestimate-ethinyl estradiol for treating dysfunctional uterine bleeding. Obstet Gynecol 2000; 96:913-920. 2. ACOG Practice Bulletin No. 14: Management of anovulatory bleeding. Int J Gynecol Obstet 2001; 72:263-271. 3. Busfield R, Farquhar C, Sowter M, et al. A randomised trial comparing the levonorgestrel intrauterine system and thermal balloon ablation for heavy menstrual bleeding. BJOG 2006; 113:257-263. 4. Cooper K, Jack S, Parkin D, Grant A. Five-year follow up of women randomised to medical management or transcervical resection of the endometrium for heavy menstrual loss: clinical and quality of life outcomes. Br J Obstet Gynaecol 2001; 108:1222-1228.