Hormone Therapy
Hormone therapy is effective in treating menorrhagia less than 50% of the time, with varying degrees of menstrual bleeding reduction. The treatment itself is associated with potential side effects that affect a woman’s quality of life, including headaches, weight gain, and nausea. Unlike a one-time NovaSure Endometrial Ablation, hormone therapy requires ongoing therapy. Women may stop taking oral contraceptives or other hormone therapies for many reasons. Many women worry about long-term health effects from the medications or they have experienced side effects. Compliance is a complex issue that needs physician follow-up. Almost one third of women stop taking hormones due to side effects or lack of efficacy.
Hormones don't reliably help with heavy menstrual bleeding
53% of women failed to achieve normal bleeding1
Results from a 3-month randomized, controlled clinical trial of a 35 mcg ethinyl estradiol formulation
Hormone Therapy can take months to achieve bleeding control2,3
OCs - 3 months required to see reductions in bleeding.2 |
With Medical Management Treatment Failure is High, Resulting in Additional Intervention4
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Data from a 5-year study of menorrhagia with women randomized to receive medical therapy or transcervical resection (N=144). Medical therapies included OCs, progestins, an antifibrinolytic, GnRH agonist or HRT. |
Drug therapy may not be an option for some patients, since oral contraceptives are contraindicated in women with a history of cardiovascular disease, blood clots, diabetes, and breast cancer. There are also serious questions regarding the potential health risks associated with long-term use of hormone therapy. Moreover, physicians have reported recently that fewer patients want to go on hormone therapy to control their menorrhagia.
Reference:
1. Davis A, Godwin A, Lippman J, et al. Triphasic norgestimate-ethinyl estradiol for treating dysfunctional uterine bleeding. Obstet Gynecol 2000; 96:913-920.
2. ACOG Practice Bulletin No. 14: Management of anovulatory bleeding. Int J Gynecol Obstet 2001; 72:263-271.
3. Busfield R, Farquhar C, Sowter M, et al. A randomised trial comparing the levonorgestrel intrauterine system and thermal balloon ablation for heavy menstrual bleeding. BJOG 2006; 113:257-263.
4. Cooper K, Jack S, Parkin D, Grant A. Five-year follow up of women randomised to medical management or transcervical resection of the endometrium for heavy menstrual loss: clinical and quality of life outcomes. Br J Obstet Gynaecol 2001; 108:1222-1228.
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